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Toxin at heart of drug recall shows holes in medical safety net

FILE PHOTO: The headquarters of the European Medicines Agency (EMA), is seen in London, Britain, April 25, 2017. REUTERS/Hannah McKay -/File Photo

By Alexandra Harney and Ben Hirschler

SHANGHAI/LONDON (Reuters) – A toxin inadvertently produced in the manufacture of a widely prescribed medicine but not spotted for years raises questions about regulators’ ability to detect risks in a sprawling global drug supply chain increasingly reliant on factories in China.

China’s Zhejiang Huahai Pharmaceutical, which produces bulk ingredients for drugmakers, told its customers in late June it had found NDMA in its valsartan, an off-patent blood pressure drug originally developed by Novartis.

The discovery means that some of the 10 billion pills containing valsartan sold worldwide last year to prevent heart attacks and strokes had traces of N-nitrosodimethylamine (NDMA), classified as a probable human carcinogen. No one has been reported as sickened by the toxin, once used in the production of liquid rocket fuel.

Regulators and industry experts say the toxin almost certainly was introduced when Huahai changed the way it produced valsartan in 2012 – a modification that was signed off on by the European body that sets standards. Subsequent inspections by European, U.S., and Chinese regulators also found no problem.

“Everyone failed – the company, the inspectors, the FDA (U.S. Food and Drug Administration), the Europeans, the Chinese,” said Philippe André, an independent pharmaceutical auditor who inspected two Huahai facilities last August and found no critical concerns. “It’s a system failure.”

Reuters was unable to determine how Huahai first discovered the problem. In a July 7 statement released through the Shanghai Stock Exchange, it said it detected the toxin during the “optimization and evaluation” of its manufacturing process.

A Novartis spokesman told Reuters that its generic drugs arm, Sandoz, spotted the NDMA in the course of intensive testing to prepare for expanding its purchases of valsartan. He declined to comment further, including on the identity of the manufacturer or when the tests took place.

Two other smaller bulk suppliers – Zhejiang Tianyu Pharmaceutical and a unit of India’s Hetero Drugs – have since also discovered traces of NDMA in some of their valsartan.

The three companies declined to comment to comment about the case.

REDUCE WASTE

Huahai said in a document released through the Shanghai Stock Exchange it changed the production process to reduce waste and improve yields.

“The NDMA impurity was produced in trace amounts during the normal manufacturing process according to the company’s current registered process,” it said in a statement on July 24.

“All changes in the company’s valsartan manufacturing process have been approved by each country’s drug regulator, and the company manufactures in compliance with legal and regulatory standards.”

The European Medicines Agency (EMA) regulator, which first publicly raised the alarm in a statement on July 5, told valsartan suppliers in a subsequent memo dated July 16 that the NDMA may have been connected to the combined use of the solvent dimethylformamide and sodium nitrite.

The FDA is also going on that hypothesis, said Janet Woodcock, director of its Center for Drug Evaluation and Research. She stressed the investigation was still going on.

“This (NDMA) was not what you look for in an inspection,” Woodcock said in an interview. “If you don’t test for this you’re not going to have an idea that it’s in there, and you’re not going to see it on an inspection.”

The European Directorate for the Quality of Medicines (EDQM), responsible for setting manufacturing standards, told Reuters it was aware the solvent was being used when it approved the changed process, but that NDMA as a by-product was unexpected and not tested for.

Detecting NDMA would have required gas chromatography coupled with mass spectrometry, a very sensitive level of testing, an EDQM spokeswoman said.

“These techniques are not normally used routinely to test pharmaceutical products,” she said.

RECALLS

Built by Novartis into the $6 billion-a-year brand Diovan, valsartan’s European and U.S. patents expired in 2011 and 2012.

Global sales totaled 10.4 billion pills last year, including combination products, healthcare data consultancy IQVIA estimates. People with high blood pressure typically take one pill daily and heart failure patients two.

More than 50 companies around the world making finished tablets from the tainted valsartan have recalled products in recent weeks, according to a Reuters analysis of national medicines agencies’ records. They include major generic drug manufacturers such as Teva Pharmaceutical Industries, Ranbaxy Laboratories, and Sandoz.

Based on the average NDMA impurity detected at Huahai of 60 parts per million (ppm), the EMA says there could be one additional case of cancer in every 5,000 people taking the highest dose for seven years.

The contamination puts a spotlight on manufacturers in China and India, which supply more than two-thirds of all active pharmaceutical ingredients used in medicines, industry executives estimate. China accounts for the lion’s share.

Huahai, founded in 1989 and listed in Shanghai in 2003, was one of the first Chinese companies to get drugs approved in the U.S. market.

The FDA has inspected the site that made the contaminated valsartan three times since 2010, its records show. European inspectors also visited regularly.

The provincial branch of the Chinese FDA (CFDA) also inspected Huahai facilities 10 times in connection with new drug applications between January 2016 and June 2018, the national online database shows.

SCRUTINY

U.S. and European regulators have increased scrutiny of Chinese and Indian drug factories after the adulteration of the blood thinner heparin sickened hundreds and caused the deaths of at least 81 Americans in 2007 and 2008.

The CFDA is also on alert.

Last month, it revealed that Changsheng Bio-technology , a vaccine maker, had fabricated data and sold ineffective vaccines for children. It also found that a diphtheria, tetanus and pertussis vaccine sold by the state-owned Wuhan Institute of Biological Products was substandard.

The fact that international inspections do not appear to have detected the NDMA contamination alarms Anders Fuglsang, a former European medicines regulator who runs a pharmaceutical consultancy in Denmark.

“We need to ask ourselves how it is possible – despite pharmacopoeias and agency guidelines, inspection programs with coordination across continents, a system of public quality control, and companies complying with all rules – that a nasty carcinogen can find its way into our drugs and be there for years without anyone noticing,” he said.

(Additional reporting by Shanghai newsroom, Zeba Siddiqui in Mumbai and Sharnya G in Bengaluru; Editing by Sonya Hepinstall)

Baby powder helping fund Islamic State in Afghanistan: report

FILE PHOTO: Afghan National Army troops prepare for an operation against insurgents in Khogyani district of Nangarhar province, Afghanistan November 28, 2017. REUTERS/Parwiz/File Photo

KABUL (Reuters) – Islamic State fighters in Afghanistan are making hundreds of thousands of dollars a year from illegal mining of talc, much of which ends up in the United States and Europe, advocacy group Global Witness reported on Tuesday.

About 500,000 tonnes of talc, used in products ranging from paint to baby powder, were exported from Afghanistan in the year to March, according to Afghan mining ministry figures cited in the group’s report.

Almost all went to Pakistan, where much of it is re-exported. Pakistan provides more than a third of U.S. imports of talc and much also ends up in the European Union, it said.

“Unwitting American and European consumers are inadvertently helping fund extremist groups in Afghanistan,” Nick Donovan, Campaign Director at Global Witness, said in a statement, calling for stronger checks on imports.

Illegal mining of gemstones and minerals such as lapis lazuli is a major source of revenue for Taliban insurgents and the report said Islamic State was fighting for control of mines in Nangarhar, the province where it has its stronghold.

Nangarhar, on the border with Pakistan, has large deposits of talc as well as minerals such as chromite and marble, and sits on major smuggling routes used for drugs and other contraband.

The report quoted a senior Islamic State militant commander as saying that wresting control of mining assets from other armed groups in Nangarhar was a priority: “The mines are in the hands of the mafia … At any price we will take the mines.”

Security officials in Afghanistan have long been concerned about the uncontrolled traffic in Nangarhar of commodities like talc and chromite, which the Global Witness report said “may be the least glamorous of conflict minerals”.

It said that while it was difficult to estimate the value of the trade to Islamic State, revenue from mining in Nangarhar could amount “anywhere from the high tens of thousands to the low millions of dollars a year”. Somewhere in the hundreds of thousands was a plausible mid-range estimate, it added.

The sum did not appear very high, it said, but the U.S. military estimated the strength of Islamic State in Nangarhar at somewhere between 750 to 2,000 fighters, meaning the funds would be a significant source of revenue to the movement.

An Afghan mining ministry spokesman said a special committee had already been established to coordinate approaches to the issue with security and intelligence services. The ministry planned a news conference this week to address some of the specific issues raised in the report.

(Reporting by James Mackenzie; Editing by Mark Heinrich)

Iran hit by global cyber attack that left U.S. flag on screens

FILE PHOTO: A man types on a computer keyboard in front of the displayed cyber code in this illustration picture taken on March 1, 2017. REUTERS/Kacper Pempel/Illustration/File Photo

DUBAI (Reuters) – Hackers have attacked networks in a number of countries including data centers in Iran where they left the image of a U.S. flag on screens along with a warning: “Don’t mess with our elections”, the Iranian IT ministry said on Saturday.

“The attack apparently affected 200,000 router switches across the world in a widespread attack, including 3,500 switches in our country,” the Communication and Information Technology Ministry said in a statement carried by Iran’s official news agency IRNA.

The statement said the attack, which hit internet service providers and cut off web access for subscribers, was made possible by a vulnerability in routers from Cisco which had earlier issued a warning and provided a patch that some firms had failed to install over the Iranian new year holiday.

A blog published on Thursday by Nick Biasini, a threat researcher at Cisco’s Talos Security Intelligence and Research Group, said: “Several incidents in multiple countries, including some specifically targeting critical infrastructure, have involved the misuse of the Smart Install protocol…

“As a result, we are taking an active stance, and are urging customers, again, of the elevated risk and available remediation paths.”

On Saturday evening, Cisco said those postings were a tool to help clients identify weaknesses and repel a cyber attack.

Iran’s IT Minister Mohammad Javad Azari-Jahromi posted a picture of a computer screen on Twitter with the image of the U.S. flag and the hackers’ message. He said it was not yet clear who had carried out the attack.

Azari-Jahromi said the attack mainly affected Europe, India and the United States, state television reported.

“Some 55,000 devices were affected in the United States and 14,000 in China, and Iran’s share of affected devices was 2 percent,” Azari-Jahromi was quoted as saying.

In a tweet, Azari-Jahromi said the state computer emergency response body MAHER had shown “weaknesses in providing information to (affected) companies” after the attack which was detected late on Friday in Iran.

Hadi Sajadi, deputy head of the state-run Information Technology Organisation of Iran, said the attack was neutralized within hours and no data was lost.

(Reporting by Dubai newsroom, additional reporting by Dustin Volz in Washington; editing by Ros Russell and G Crosse)

South Korea’s Moon says three-way summit with North Korea, U.S. possible

FILE PHOTO: South Korean President Moon Jae-in delivers a speech during a ceremony celebrating the 99th anniversary of the March First Independence Movement against Japanese colonial rule, at Seodaemun Prison History Hall in Seoul, South Korea, March 1, 2018. REUTERS/Kim Hong-Ji

By Hyonhee Shin and Christine Kim

SEOUL (Reuters) – South Korean President Moon Jae-in said on Wednesday a three-way summit with North Korea and the United States is possible and that talks should aim for an end to the nuclear threat on the Korean peninsula.

Moon is planning a meeting with North Korean leader Kim Jong Un next month after a flurry of diplomatic activity in Asia, Europe and the United States. U.S. President Donald Trump has also said he would meet Kim by the end of May.

“A North Korea-U.S. summit would be a historic event in itself following an inter-Korean summit,” Moon said at the presidential Blue House in Seoul after a preparatory meeting for the inter-Korean summit.

“Depending on the location, it could be even more dramatic. And depending on progress, it may lead to a three-way summit between the South, North and the United States,” he said.

Seoul officials are considering the border truce village of Panmunjom, where Moon and Kim are set for a one-day meeting, as the venue for talks between not only Kim and Moon but also a possible three-way meeting.

A Blue House official, speaking on condition of anonymity, said Moon did not specifically refer to Panmunjom or that a three-way summit had been discussed with Washington before the president spoke.

The rush of recent diplomatic contacts began in the lead-up to the Winter Olympics in South Korea last month and helped ease tensions on the Korean peninsula caused by North Korea’s pursuit of its nuclear and missile programs in defiance of United Nations Security Council sanctions.

South Korea wants to hold high-level talks with North Korea on March 29 to discuss a date and agenda for the inter-Korean summit and make a formal request to the North on Thursday, Moon’s presidential office said.

North and South Korean officials should be able to agree on when the summit between Moon and Kim will take place once the officials from both sides meet this month, the Blue House official said.

‘CLEAR GOAL’

Moon said the series of summits should aim for a “complete end” to the nuclear and peace issues on the Korean peninsula.

He said he has a “clear goal and vision”, which is for the establishment of a lasting peace to replace the ceasefire signed at the end of the 1950-53 Korean war. It also includes the normalization of North Korea-U.S. relations, the development of inter-Korean ties, and economic cooperation involving Pyongyang and Washington, he said.

However, the United States must also add its guarantee in order for peace to come about, Moon said.

“Whether the two Koreas live together or separately, we have to make it in a way that they prosper together and in peace, without interfering or causing damage to each other,” Moon said.

The Blue House official said this could mean stopping propaganda broadcasts at the border that are commonly blasted from both sides over loudspeakers. The official could not say whether “interference” also referred to criticism over widely recognized human rights violations in North Korea.

South Korea and the United States will resume joint military drills next month, although the exercises are expected to overlap with the summit between the two Koreas.

Seoul and Washington delayed the annual drills until after the Winter Olympics, helping to foster conditions for a restart of such talks.

North Korea regularly denounces the drills as preparation for war but a South Korean special envoy has said Kim understood that the allies must continue their “routine” exercises. That exchange has not been confirmed.

The North’s official KCNA news agency said on Wednesday a “dramatic atmosphere for reconciliation” had been created in cross-border ties and there had also been a sign of change in North Korea-U.S. relations.

That was “thanks to the proactive measure and peace-loving proposal” made by Pyongyang, not Trump’s campaign to put maximum pressure on the country, KCNA said in a commentary.

The Blue House official also said earlier on Wednesday South Korea was in discussions with China and Japan for a three-way summit in Tokyo in early May. The three countries have not held such a meeting since November 2015, with relations soured by historical and territorial tensions.

(Reporting by Hyonhee Shin and Christine Kim; Editing by Paul Tait)

Facing far-right challenge, minister says Islam ‘doesn’t belong’ to Germany

German Interior Minister Horst Seehofer is sworn-in by Parliament President Wolfgang Schaeuble in Germany's lower house of parliament Bundestag in Berlin, Germany, March 14, 2018. REUTERS/Kai Pfaffenbach

By Michelle Martin

BERLIN (Reuters) – New Interior Minister Horst Seehofer said Islam does not belong to Germany, and set out hardline immigration policies in his first major interview since being sworn in this week, as he sought to see off rising far-right challengers.

His comments put him on a collision course with Chancellor Angela Merkel, who on Friday reiterated her long-held view that Islam was a part of Germany, even if the country was traditionally characterized by Christianity and Judaism.

“Islam does not belong to Germany,” Seehofer, a member of Merkel’s CSU Bavarian allies who are further to the right than her own Christian Democrats (CDU), told Bild newspaper in an interview published on Friday.

Seehofer said he would push through a “master plan for quicker deportations” and classify more states as ‘safe’ countries of origin, which would make it easier to deport failed asylum seekers.

Seehofer is particularly keen to show his party is tackling immigration ahead of Bavaria’s October regional election, when the far-right Alternative for Germany (AfD) is expected to enter that state assembly.

Both Merkel’s conservatives and their centre-left coalition partners – the Social Democrats – lost ground to the anti-immigrant AfD in September’s national election following the arrival in Germany of more than a million migrants and refugees.

Merkel, who has faced strong criticism from some Germans as well as elsewhere in Europe for agreeing to take in so many migrants, most of them Muslims, reaffirmed on Friday her vision of an inclusive, multi-ethnic Germany.

“There are now four million Muslims living in Germany and they practice their religion here and these Muslims belong to Germany, as does their religion – Islam,” she said.

“LIVE WITH US”

Many of the Muslims living in Germany are of Turkish origin. But a majority of those who have arrived in the past three years are from Syria, Iraq and other conflict zones in the Middle East and beyond.

Seehofer’s comments come at a sensitive time for Germany’s Muslim community. Several organisations representing them complained on Thursday that politicians were not showing enough solidarity after a spate of attacks on mosques.

“Of course the Muslims living here do belong to Germany,” Seehofer told Bild, but added that Germany should not give up its own traditions or customs, which have Christianity at their heart.

“My message is: Muslims need to live with us, not next to us or against us,” he said.

Andre Poggenburg, head of the AfD in the eastern state of Saxony, said Seehofer was copying his party with a view to Bavaria’s October regional election: “Horst Seehofer has taken this message from our manifesto word for word.”

The far-left Linke and Greens condemned Seehofer’s message, and the Social Democrats’ Natascha Kohnen told broadcaster n-tv: “Saying that incites people against each other at a time when we really don’t need that. What we really need is politicians who bring people together.”

In their coalition agreement, Merkel’s CDU/CSU conservative bloc and the Social Democrats agreed they would manage and limit migration to Germany and Europe to avoid a re-run of the 2015 refugee crisis.

They also said they did not expect migration (excluding labor migration) to rise above the range of 180,000 to 220,000 per year.

(Reporting by Michelle Martin; Editing by Gareth Jones)

Homegrown attacks rising worry in U.S. as Islamic State weakens abroad

By Joseph Ax

NEW YORK (Reuters) – The online video’s message was clear: Supporters of Islamic State who could not travel overseas to join the militant group should carry out attacks wherever they were in the United States or Europe.

Bangladeshi immigrant Akayed Ullah, 27, followed those instructions on Monday when he tried to set off a homemade bomb in one of New York’s busiest commuter hubs, in an attack that illustrates the difficulty of stopping “do-it-yourself” attacks by radicals who act alone.

While harder to stop than attacks coordinated by multiple people – whose communications may be more easily monitored by law enforcement or intelligence agencies – they also tend to do less damage. Ullah was the person most seriously wounded when his bomb ignited but did not detonate in an underground passageway linking the Port Authority Bus Terminal and the Times Square subway statin; three others sustained lesser injuries.

“They tend to be less organized and less deadly,” said Seamus Hughes, a former adviser at the U.S. government’s National Counterterrorism Center. “That’s because you’re dealing with more, for lack of a better word, amateurs.”

The do-it-yourself style of attack is on the rise in the United States, according to research by the Program on Extremism at George Washington University, where Hughes is deputy director.

The United States has seen 19 attacks perpetrated by Islamic State-inspired people since the group declared a “caliphate” in June 2014 after capturing broad swaths of Iraq and Syria. Of those, 12 occurred in 2016 and 2017, almost twice as many as in the two preceding years.

“You’re going to see continued numbers of plots and, unfortunately, attacks,” Hughes said.

Ullah began immersing himself in Islamic State propaganda as early as 2014, three years after he arrived in the United States as a legal immigrant, according to federal prosecutors who charged him with terrorism offenses. They said in court papers that Ullah’s computer records showed that he viewed ISIS videos urging supporters of the group to launch attacks where they lived.

Experts said the success of Western allies in retaking most of Islamic State’s territory could inspire more attacks out of anger or vengeance.

“No group has been as successful at drawing people into its perverse ideology as ISIS,” Federal Bureau of Investigation Director Christopher Wray said in congressional testimony last week. “Through the internet, terrorists overseas now have access into our local communities to target and recruit our citizens.”

National security analysts generally divide such perpetrators into three broad categories.

Some attackers act at the direction of a group, like the Islamic State-backed militants who carried out coordinated attacks in Paris in 2015, killing 130; others have some limited contact with an organization but act largely on their own. A third type has no communication with a group but engage in violence after being radicalized by online propaganda.

It is easier for trained, battle-hardened ISIS fighters to travel from the Middle East to Europe than for them to reach the United States. That helps explain why U.S. attacks have largely been the work of “self-made” terrorists, said Brandeis University professor and radicalization expert Jytte Klausen.

“In these recent cases, we’ve seen very few indications that there was any type of direct training,” Klausen said.

Self-directed perpetrators are the hardest for investigators to identify. Their ranks appear to include Ullah, as well as two other recent New York attackers: Ahmad Rahimi, the man who injured 30 with a homemade bomb in Manhattan in September 2016, and Sayfullo Saipov, the Uzbek immigrant accused of killing eight by speeding a rental truck down a bike lane in October.

While that type of attacker typically is less destructive, there are important exceptions. Oklahoma City bomber Timothy McVeigh and Terry Nichols killed 168 people, and Omar Mateen gunned down 49 people at a gay nightclub in Orlando last year.

“A single individual or two can still create a lot of damage,” said Max Abrahms, a professor at Northeastern University who studies terrorism. “But they’re not able to wage sustained terrorist campaigns.”

(This story has been refiled to restore dropped word “as” in 6th paragraph)

(Reporting by Joseph Ax; Editing by Scott Malone and Jonathan Oatis)

Britons can change terms of Brexit to diverge from EU: pro-Brexit minister Gove

By Alistair Smout

LONDON (Reuters) – British voters will be able to change the terms of the country’s relationship with the European Union after leaving the bloc if they don’t like the final Brexit deal, senior cabinet minister and pro-Brexit lawmaker Michael Gove said on Saturday.

Britain and the EU achieved “sufficient progress” in Brexit negotiations on Friday to allow them to move on to discussing future trade ties, in a move welcomed by Gove and other Brexit supporters in Prime Minister Theresa May’s Conservative Party.

However, while Gove, who is Britain’s environment minister, reiterated his support for May, he gave succour to critics of the deal by saying that if Britons were dissatisfied with the terms of Brexit, future governments could change it.

“The British people will be in control. By the time of the next election, EU law and any new treaty with the EU will cease to have primacy or direct effect in UK law,” Gove wrote in a column in the Daily Telegraph.

“If the British people dislike the arrangement that we have negotiated with the EU, the agreement will allow a future government to diverge.”

Britain is due to exit the EU in March 2019. The next election is not scheduled until 2022, though there has been speculation in British media that it could come earlier, given May’s lack of a parliamentary majority and deep divisions within her party about Brexit.

Some eurosceptic voices outside the government have said that May has betrayed British “leave” voters and given in to EU demands with the agreement.

TOUGH WEEK

It has been a tough week for May after Northern Ireland’s small Democratic Unionist Party (DUP) – whose support she needs in parliament – unexpectedly blocked an initial deal on Monday, leaving Britain and the EU scrambling to find wording acceptable to all sides ahead of next week’s summit of EU leaders.

While agreement was eventually reached on Friday, Gove said that all UK proposals were provisional on a final deal being done, and even then, that arrangement could be revisited by future governments.

Matthew Parris, an anti-Brexit columnist and former Conservative lawmaker, told BBC radio that Gove might envisage a situation in which he would be spearheading a new approach to Brexit.

But Gove, who was briefly in the running to lead the party last year, praised May on Saturday, and said the deal was a result of her “tenacity and skill”.

Fellow pro-Brexit cabinet colleague Andrea Leadsom defended his comments, saying it did not imply that May would be replaced before the next election.

“It’s simply the case that in taking back control (from Brussels)… it will be for the voters to determine what future governments do,” Leadsom told BBC radio. “I think it is a statement of the obvious.”

(Reporting by Alistair Smout; Editing by Gareth Jones)

European states push U.S. for detailed Middle East peace proposals

By Michelle Nichols

UNITED NATIONS (Reuters) – Britain, France, Germany, Sweden and Italy called on the United States on Friday to put forward detailed proposals for peace between Israel and the Palestinians and described as “unhelpful” a decision by President Donald Trump to recognize Jerusalem as Israel’s capital.

Trump’s reversal of decades of U.S. policy on Wednesday sparked a Palestinian “day of rage” on Friday. Thousands of Palestinians demonstrated, scores were hurt and at least one was killed in clashes with Israeli troops.

Amid anger in the Arab world and concern among Washington’s Western allies, the United Nations Security Council met on Friday at the request of eight of the 15 members – Britain, France, Sweden, Bolivia, Uruguay, Italy, Senegal and Egypt.

In a joint statement after the meeting, Britain, France, Germany, Sweden and Italy said the U.S. decision, which includes plans to move the U.S. embassy to Jerusalem from Tel Aviv, was “unhelpful in terms of prospects for peace in the region.”

“We stand ready to contribute to all credible efforts to restart the peace process, on the basis of internationally agreed parameters, leading to a two-State solution,” they said. “We encourage the U.S. Administration to now bring forward detailed proposals for an Israel-Palestinian settlement.”

Egypt’s U.N. Ambassador Amr Aboulatta said the U.S. decision would have “a grave, negative impact” on the peace process.

U.S. Ambassador to the United Nations Nikki Haley said the Washington has credibility as a mediator with both Israel and the Palestinians and accused the United Nations of damaging rather than advancing peace prospects with unfair attacks on Israel.

“Israel will never be, and should never be, bullied into an agreement by the United Nations, or by any collection of countries that have proven their disregard for Israel’s security,” Haley said.

ESCALATION RISK

Haley said Trump was committed to the peace process and that the United States had not taken a position on Jerusalem’s borders or boundaries and was not advocating any changes to the arrangements at the holy sites.

“Our actions are intended to help advance the cause of peace,” she said. “We believe we might be closer to that goal than ever before.”

Earlier on Friday, U.S. Secretary of State Rex Tillerson said during a news conference in Paris that any final decision on the status of Jerusalem would depend on negotiations between Israelis and Palestinians.

United Nations Middle East envoy Nickolay Mladenov warned there was a risk of violent escalation.

“There is a serious risk today that we may see a chain of unilateral actions, which can only push us further away from achieving our shared goal of peace,” Mladenov told the U.N. Security Council.

Israel considers all of Jerusalem to be its capital. Palestinians want the eastern part of the city as the capital of a future independent state of their own.

Most countries consider East Jerusalem, which Israel annexed after capturing it in the 1967 Middle East War, to be occupied territory, including the Old City, home to sites considered holy to Muslims, Jews and Christians alike.

A U.N. Security Council resolution adopted in December last year “underlines that it will not recognize any changes to the 4 June 1967 lines, including with regard to Jerusalem, other than those agreed by the parties through negotiations.”

That resolution was approved with 14 votes in favor and an abstention by former U.S. President Barack Obama’s administration, which defied heavy pressure from long-time ally Israel and Trump, who was then president-elect, for Washington to wield its veto.

(Reporting by Michelle Nichols; Editing by Frances Kerry and James Dalgleish)

Catalan separatists march in Brussels

By Clement Rossignol

BRUSSELS (Reuters) – Nearly 50,000 people marched through Brussels’ European quarter on Thursday in support of Catalan independence and the region’s president, who has avoided arrest in Spain by taking refuge in Belgium.

Before Carles Puigdemont addressed the crowd, many draped in Catalan flags, police estimated its size at 45,000. There were chants of “Puigdemont, President” from a generally good-natured throng, many of whom had traveled from Spain for the occasion.

Some carried placards criticizing the European Union for not pressuring Madrid. One sign showed the face of European Commission President Jean-Claude Juncker with the question: “Democracy? Some defend it when it suits them. Shame on them.”

Gloria Cot, a clerk from Barcelona who had just arrived in by coach, said: “Brussels is a kind of a loudspeaker for us.

“It is a loudspeaker so that people can know that we really don’t have a 100 percent democracy in Spain and that Catalonia has always been subjected to problems with Spain.”

Nuria Salvat, a student from Tarragona in Catalonia, said she had come to demand freedom for “political prisoners” – members of Puigdemont’s administration held in jail in Spain – and to support Puigdemont himself, who faces jail if he returns.

“Spain,” she said, “has always treated us very badly.”

A short distance away in the EU executive’s headquarters, Juncker’s deputy Frans Timmermans told reporters he welcomed the “very positive atmosphere” of the demonstration, which took place as campaigning has got under way for a Catalan election which Madrid hopes can end the deadlock created by its refusal to recognize an independence vote Puigdemont held in September.

But, the former Dutch foreign minister said, there was no change to Commission policy that the dispute with the Barcelona authorities, now removed from office, remains an internal one in which the EU has no need to intervene because Spain’s democratic constitution is functioning in line with EU values.

Accusing Puigdemont and his allies of undermining the rule of law by choosing to ignore a Spanish constitutional ban on secession rather than trying to change the constitution, Timmermans said they were jeopardizing basic freedoms and noted there had been big rallies in Spain on both sides of the debate.

“If you do not agree with law, you can organize yourselves to change the law or the constitution,” he said. “What is not permissible under the rule of law is to just ignore the law.”

(Additional reporting and writing by Alastair Macdonald; editing by Mark Heinrich)

Millions of insecure gadgets exposed in European cities: report

LONDON (Reuters) – A year after a wave of denial-of-service attacks knocked out major websites around the world, millions of unsecured printers, network gear and webcams remain undefended against attack across major European cities, a report published on Tuesday said.

Computer security company Trend Micro <4704.T> said that Berlin has more than 2.8 million insecure devices, followed closely by London with more than 2.5 million exposed gadgets. Among the top 10 capitals, Rome was lowest with nearly 300,000 visible unsecured devices, the researchers said.

The study was based on calculating the number of exposed devices in major European cities using Shodan, a search engine that helps to identify internet-linked equipment.

Trend Micro said that electronics users must take responsibility for managing their own internet-connected devices because of the failure by many gadget manufacturers to build in up-front security by default in their products.

The warning comes one year after a wave of attacks using so-called botnets of infected devices caused outages on popular websites and knocked 900,000 Deutsche Telekom <DTEGn.DE> users off the internet. (http://reut.rs/2BjdRII)

Computer experts say the failure to patch millions of insecure devices after last year’s Mirai denial-of-service attacks means it is only a question of time before further broad-based outages occur.

Research company Gartner recently forecast that there would be 8.4 billion connected products or devices in 2017, up 31 percent from 2016, and expects the number to triple by 2020. (https://goo.gl/thR54Q)

(Reporting by Jamillah Knowles; Editing by Eric Auchard and David Goodman)

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